Complete
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6 8 10 13 16 19 21 7 1 18 17 2 9 15 14 3 12 20 11 4 5
  1. 1a Painkiller (9)
  2. 8a Third most populous Japanese city (5)
  3. 9a Hercule Poirot's nationality (7)
  4. 10a Pacts (8)
  5. 11a Largest island of the Inner Hebrides (4)
  6. 13a Morbid fear (6)
  7. 14a Develop in such a way as to cause a problem (4,2)
  8. 16a Snug (4)
  9. 17a Don Quixote's region of Spain (2,6)
  10. 19a Young mares (7)
  11. 20a Birds that fly in a skein (5)
  12. 21a Final chess move (9)
  13. 1d Building used for butchery (8)
  14. 2d Saunters (6)
  15. 3d Audacity (4)
  16. 4d Awkward situation (6,6)
  17. 5d Thought about (12)
  18. 6d Rodgers and Hammerstein musical (5,7)
  19. 7d French miss (12)
  20. 12d Geometric shape (eternal, maybe) (8)
  21. 15d Sickness (6)
  22. 18d Flower — colour (4)